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Dabigatran etexilate retards the initiation and progression of atherosclerotic lesions and inhibits the expression of oncostatin M in apolipoprotein E-deficient mice.
Preusch MR, Ieronimakis N, Wijelath ES, Cabbage S, Ricks J, Bea F, Reyes M, van Ryn J, Rosenfeld ME. Preusch MR, et al. Drug Des Devel Ther. 2015 Sep 10;9:5203-11. doi: 10.2147/DDDT.S86969. eCollection 2015. Drug Des Devel Ther. 2015. PMID: 26392754 Free PMC article.
This study was designed to investigate the effects of thrombin inhibition on the initiation and progression of atherosclerosis and on the expression of oncostatin M. METHODS: Apolipoprotein E-deficient mice at different ages were fed the thrombin inhibitor dabigatran etexi …
This study was designed to investigate the effects of thrombin inhibition on the initiation and progression of atherosclerosis and on the ex …
Role of fluid dynamics on the healing of an in vivo tissue engineered vascular graft.
Lyman DJ, Stewart SF, Murray-Wijelath J, Wijelath E. Lyman DJ, et al. J Biomed Mater Res B Appl Biomater. 2006 May;77(2):389-400. doi: 10.1002/jbm.b.30436. J Biomed Mater Res B Appl Biomater. 2006. PMID: 16278848
A polyester (PET) reinforced fibrin-FN-VEGF-TGFbeta vascular graft, formed by a four-step preclotting technique of a porous PET arterial graft, shows the overlapping inflammation, proliferation, and remodeling steps of normal wound healing when implanted in the descending thoraci …
A polyester (PET) reinforced fibrin-FN-VEGF-TGFbeta vascular graft, formed by a four-step preclotting technique of a porous PET arterial gra …
Expression of vascular endothelial growth factor receptors in smooth muscle cells.
Ishida A, Murray J, Saito Y, Kanthou C, Benzakour O, Shibuya M, Wijelath ES. Ishida A, et al. J Cell Physiol. 2001 Sep;188(3):359-68. doi: 10.1002/jcp.1121. J Cell Physiol. 2001. PMID: 11473363
SMCs migrated significantly in response to VEGF(165) and VEGF-E, whereas Placenta Growth Factor (PlGF) induced migration only at higher concentrations. ...VSMCs did not significantly proliferate in response to VEGF(165), PlGF, and VEGF-E. In conclusion, our studies …
SMCs migrated significantly in response to VEGF(165) and VEGF-E, whereas Placenta Growth Factor (PlGF) induced migration only at high …